The article is devoted to the study of the globalization factor in the national system  of public administration. The main goal is to create understanding of the entity, organizational and legal basics, characteristics and key components of state anti-crisis management in the context of globalization and the negative effects of the crisis and sanctions restrictions. The article presents the analysis of a specific Manager of anti-crisis actions, taking into account opportunities, difficulties and prospects of moving in the direction of sustainable socio-economic and political development. While sanctions are considered as a special product of globalization and a unipolar world order. The article analyzes the basic aspects, principles and priorities of state anti-crisis strategy and the respective crisis management plans and operational decisions. Presented as General recommendations, and analysis of real measures and mechanisms of state anti-crisis management. Emphasizes the need for a more professional, flexible and high-quality work of the state apparatus in crisis and sanctions restrictions – new level of integration of measures for strategic and operational management, a more rigorous audit of socio-economic risks and projected a sober calculation of the possible difficulties and contradictions. The author avoids unambiguous situational judgment, trying to distance themselves from formal generalizations, one-sided assessments and idealistically oriented recommendations.