Nowadays solving the problem of homelessness is not among the priorities of the State social policy. This fact is caused by the complexity of the problem scale’s evaluation, as well as a lack of relevant research. Contemporary studies are devoted to a nature, causes of appearance, negative aspects, some methods of dealing with the homelessness phenomena, but those investigations are not much oriented at the development of the systemized approach to such a problem group of citizens. The paper summarizes the results of the survey of foreign researchers and the analysis of the approaches developed abroad. The authors fixed upon a reasonable and relevant approach, based on the specificity of a national scientific and managerial tradition. The comprehensive approach to solving the problem of homelessness, as well as social adaptation and re-socialisation of homeless people in the Russian regions is described in the paper. The authors developed a Model of social adaptation and re-socialisation of homeless people in a region. The Model presents a schematic description of an activity system that coordinate goals, tasks, responsible authorities, instruments, stages of performance, financial sources and criteria for effectiveness evaluation with each other. The developed Model of social adaptation and re-socialisation of homeless people will allow improving the process of inter-departmental interaction and providing the systematic approach to dealing with the homeless people.